Description
This project leverages Next-Generation Sequencing (NGS) to track the evolution of SARS-CoV-2 and influenza viruses circulating in Umbria, aiding outbreak management and surveillance.
By analyzing mutations in the Spike protein, particularly in key domains affecting SARS-CoV-2 viral transmission and immune evasion, we aim to assess variant prevalence and its impact on disease severity.
Additionally, in collaboration with the Perugia Hospital (Azienda Ospedaliera di Perugia), we apply targeted whole-genome sequencing to identify and characterize Influenza A (IAVs) and B (IBVs) strains. This approach enhances our understanding of viral mutations beyond traditional serotyping, and is crucial for contributing to the development of more effective vaccines and treatments at both regional and global levels.
By analyzing mutations in the Spike protein, particularly in key domains affecting SARS-CoV-2 viral transmission and immune evasion, we aim to assess variant prevalence and its impact on disease severity.
Additionally, in collaboration with the Perugia Hospital (Azienda Ospedaliera di Perugia), we apply targeted whole-genome sequencing to identify and characterize Influenza A (IAVs) and B (IBVs) strains. This approach enhances our understanding of viral mutations beyond traditional serotyping, and is crucial for contributing to the development of more effective vaccines and treatments at both regional and global levels.
Collaborators
Università degli Studi di Perugia:
Dipartimento di Medicina e Chirurgia - Antonella Mencacci
Azienda Ospedaliera di Perugia:
Microbiologia
Dipartimento di Medicina e Chirurgia - Antonella Mencacci
Azienda Ospedaliera di Perugia:
Microbiologia
Related publications
SARS-CoV-2 Molecular Evolution: A Focus on Omicron Variants in Umbria, Italy
Giulia Bicchieraro, Raffaella Ciurnelli, Alessandro Graziani, Alicia Yoke Wei Wong, Barbara Camilloni, Antonella Mencacci, Roberta Spaccapelo
Microorganisms, vol. 12, 2024 Jun, p. 1330
Elisabetta Schiaroli, Anna Gidari, Giovanni Brachelente, Giulia Bicchieraro, Roberta Spaccapelo, Sabrina Bastianelli, Sara Pierucci, Chiara Busti, Carlo Pallotto, Lisa Malincarne, Barbara Camilloni, Flavio Falcinelli, Giuseppe Vittorio De Socio, Alfredo Villa, Antonella Mencacci, Daniela Francisci
Journal of Clinical Virology: The Official Publication of the Pan American Society for Clinical Virology, vol. 168, 2023 Nov, p. 105584
Immediate reinfection with Omicron variant after clearance of a previous SARS-CoV-2 infection
Antonella Mencacci, Alessio Gili, Barbara Camilloni, Giulia Bicchieraro, Roberta Spaccapelo, Carla Bietta, Fabrizio Stracci
Journal of Infection and Public Health, vol. 15, 2022 Sep, pp. 983--985