Immune system imbalances play a crucial role in health and disease, contributing to conditions ranging from immune-mediated disorders to increased cancer risk. Throughout life, the immune response can become either overactive or suppressed, disrupting cellular communication and leading to pathological conditions.

To better understand these mechanisms, we are developing an innovative organoid and tumoroid research platform. Using advanced 3D technology, this platform will enable the study of tissue microenvironments and vesicle release in cancer and immune-related diseases.

By fostering interdisciplinary collaboration within our university, we aim to create a cutting-edge resource that deepens our understanding of disease progression and paves the way for novel therapeutic strategies.

Università degli Studi di Perugia:
Dipartimento di Medicina e Chirurgia - Teresa Zelante (PI), Maria Agnese della Fazia, Francesca Fallarino, Valentina Franzoni, Giacomo Cafaro, Oxana Bereschenko
Dipartimento di Chimica, Biologia e Biotecnologie - Sandra Buratta
Dipartimento di Medicina Veterinaria - Luisa Pascucci

Fondo Ricerca di Ateneo 2023